• Low-grade
  • 掕宆僇儖僠僲僀僪
• Intermediate-grade
  • 旕掕宆僇儖僠僲僀僪
• High-grade
  • 戝嵶朎恄宱撪暘斿娻
  • 彫嵶朎娻

Tumorlet

庡偵嵶婥娗巟廃埻偵恄宱撪暘斿嵶朎偑寢愡傪偮偔傞傕偺偱偡丅塃偼柶塽愼怓偱恄宱撪暘斿儅乕僇乕偺侾偮偱偁傞CD56(NCAM)偑梲惈偱偁傞偙偲傪帵偟傑偡丅 Tumorlet偼俆倣倣枹枮偱偁傝丄5mm埲忋偺傕偺偼丄僇儖僠僲僀僪偲偟傑偡丅

僇儖僠僲僀僪庮釃

掕媊丗恄宱撪暘斿惈偺埆惈忋旂惈庮釃丅掕宆僇儖僠僲僀僪偲旕掕宆僇儖僠僲僀僪偵暘椶偡傞丅

掕宆僇儖僠僲僀僪偲旕掕宆僇儖僠僲僀僪偺恌抐婎弨

	掕宆僇儖僠僲僀僪	旕掕宆僇儖僠僲僀僪
峔憿	椶婍姱峔憿丄嶕忬丄搰忬丄嶒忬丄儕儃儞忬丄儘僛僢僩峔憿
妀暘楐憸乮侾侽崅攞帇栰乯	0-1屄	2-10屄
夡巰	側偄	偁傞乮彫偝偄乯

僇儖僠僲僀僪偼椶婍姱峔憿丄嶕忬丄搰忬丄嶒忬丄儕儃儞忬丄儘僛僢僩峔憿側偳偺摿挜傪傕偪傑偡丅 掕宆僇儖僠僲僀僪偼丄妀暘楐憸偑10崅攞帇栰偱侽偐1屄偱丄夡巰偼擣傔傑偣傫丅 旕掕宆僇儖僠僲僀僪偼丄椶婍姱峔憿丄嶕忬丄搰忬丄嶒忬丄儕儃儞忬丄儘僛僢僩峔憿側偳偺摿挜傪傕偮揰偼掕宆揑僇儖僠僲僀僪偲摨偠偱偡丅 堘偄偼丄妀暘楐憸偑10崅攞帇栰偱俀亅侾0屄丄偁傞偄偼夡巰憙傪擣傔傞偙偲偱偡丅夡巰憙偼傆偮偆彫偝偔丄戝偒側夡巰偼傒傜傟傑偣傫丅 Tumorlet偼掕宆僇儖僠僲僀僪偵帡偰偄傑偡偑丄戝偒偝偑彫偝偔丄俆倣倣傛傝彫偝偄傕偺傪偄偄傑偡丅 戝嵶朎恄宱撪暘斿娻媦傃彫嵶朎娻偲旕掕宆僇儖僠僲僀僪偺娪暿偼丄慜2幰偼偄偢傟傕妀暘楐憸偺悢偑懡偄偙偲偵傛傝傑偡丅

掕宆僇儖僠僲僀僪

椶婍姱峔憿傪帵偟傑偡丅塃偵奼戝憸傪帵偟傑偡丅庮釃嵶朎偺妀偼椶墌宍偱丄岲巁惈偺朙晉側嵶朎幙傪桳偟傑偡丅儘僛僢僩條峔憿傪擣傔傑偡丅

旕掕宆僇儖僠僲僀僪

椶婍姱峔憿傪擣傔丄夡巰傪擣傔傑偡丅 塃偺奼戝憸偼丄妀偺僋儘儅僠儞偑憹検偟丄嵶朎幙偑彮側偄偙偲偑傢偐傝傑偡丅 儘僛僢僩條峔憿傪擣傔傑偡丅妀暘楐憸偼偁傑傝擣傔傜傟傑偣傫丅

戝嵶朎恄宱撪暘斿娻

掕媊丗儘僛僢僩丄朎憙曈墢偺嶒忬攝楍側偳慻怐妛揑偵恄宱撪暘斿峔憿傪帵偟丄柶塽愼怓偱恄宱撪暘斿儅乕僇乕偑梲惈偵側傞旕彫嵶朎娻丅

椶婍姱峔憿丄嶕忬丄儘僛僢僩條丄嶒忬攝楍傪帵偟傑偡丅 嵶朎幙偼拞摍検偐傜朙晉偱丄妀彫懱偑栚棫偪傑偡丅 妀暘楐憸偼侾侽崅攞帇栰偱11屄埲忋偱丄暯嬒偼75屄偱偡丅 峀偄斖埻偺夡巰憙傪擣傔傑偡丅 戝嵶朎恄宱撪暘斿娻偲恌抐偡傞偨傔偵偼丄柶塽愼怓偱恄宱撪暘斿儅乕僇乕偑梲惈偱偁傞偙偲傪妋擣偡傞昁梫偑偁傝傑偡丅

戝嵶朎恄宱撪暘斿娻偺慻怐憸傪帵偟傑偡丅 嵍偵庛奼戝傪帵偟傑偡丅庮釃嵶朎偼朎憙傪宍惉偟丄峀斖側夡巰憙傪擣傔傑偡丅 塃偵嫮奼戝傪帵偟傑偡丅庮釃嵶朎偼朎憙偺曈墢偱嶒忬攝楍傪帵偟傑偡丅嵶朎幙偼斾妑揑朙晉偱丄岲巁惈偱偡丅儘僛僢僩峔憿傪擣傔傑偡丅偒傢傔偰戝偒偄庮釃嵶朎偑弌尰偟偰偄傑偡丅


崿崌宆戝嵶朎恄宱撪暘斿娻
戝嵶朎恄宱撪暘斿娻偲丄態娻丄滸暯忋旂娻丄朼悗嵶朎娻丄嫄嵶朎娻偑崿嵼偡傞庮釃偱偡丅

戝嵶朎恄宱撪暘斿娻偺嵶朎強尒
堦斒揑偵丄戝嵶朎恄宱撪暘斿娻偼庤弍偵傛傝揈弌偝傟偨昗杮偱恌抐偝傟傑偡丅偟偐偟丄恑峴偟偨徢椺偱偼庤弍偵傛傝揈弌偡傞偙偲偑崲擄偱丄歕醾傗婥娗巟嬀偵傛傞惗専傗嵶朎恌偱娻偺慻怐宆傪寛掕偡傞昁梫偑偁傝傑偡丅

偙偺僗儔僀僪偼庤弍偵傛傝揈弌偝傟偨昗杮偱丄戝嵶朎恄宱撪暘斿娻偲恌抐偝傟偨徢椺偺庮釃撴報偵傛傞嵶朎恌強尒偱偡丅 嵍忋偵庮釃嵶朎偑僔乕僩忬偵攝楍偟偰偄傞強尒傪帵偟傑偡丅塃忋偼朙晉側嵶朎幙傪桳偡傞懡妏宍偺庮釃嵶朎偑丄暯柺揑偱屒棫惈偵弌尰偟偰偄傞強尒傪帵偟傑偡丅 妀枌偼敄偔嬒堦偱偡丅妀彫懱偼侾亅俀屄尒傜傟傑偡丅 彫嵶朎娻偲摨條偵妀慄傪擣傔傑偡丅 嵍壓偵帵偡儘僛僢僩條峔憿傕懡偔偺徢椺偱擣傔傜傟傑偟偨丅 塃壓偵嬌傔偰戝偒側棁妀忬偺嵶朎偑屒棫惈偵弌尰偟偰偄傞強尒傪帵偟傑偡丅妀彫懱偼懡悢擣傔傜傟傑偡丅 偙偺傛偆側強尒偑傒傜傟偨応崌丄嵶朎恌偱傕戝嵶朎恄宱撪暘斿娻偲恌抐偡傞偙偲偑壜擻偱偁傞偲峫偊傑偡丅

彫嵶朎娻

掕媊丗嵶朎幙偑彮側偔丄嵶朎嫬奅偑晄柧椖偱丄妀栐偑旝嵶偱丄妀彫懱偑側偄偐栚棫偨側偄彫宆偺嵶朎偐傜側傞埆惈忋旂惈庮釃丅嵶朎偺宍偼墌宍丄懭墌宍偁傞偼朼悗宍偱偁傞丅妀偺憡屳埑攔憸偑挊柧偱偁傞丅峀斖側夡巰傪擣傔丄妀暘楐憸偑懡偄丅懡偔偺彫嵶朎娻偼恄宱撪暘斿儅乕僇乕偑梲惈偱偁傞丅

彫宆偺嵶朎偐傜側傞埆惈忋旂惈庮釃偱丄庮釃嵶朎偺戝偒偝偼丄儕儞僷媴偺俁攞枹枮偱偡丅 妀暘楐憸偑懡偔丄暯嬒偼60屄埲忋偱偡丅 WHO戞3斉偵偼丄彫嵶朎娻偼HE愼怓偱恌抐偡傞偙偲偑壜擻偱丄柶塽愼怓傗揹巕尠旝嬀偵傛傝恄宱撪暘斿暘壔傪徹柧偡傞昁梫偑側偄偲婰嵹偝傟偰偄傑偡偑丄戞4斉偵偼丄忋旂惈庮釃偱偁傝丄恄宱撪暘斿暘壔傪妋擣偡傞偨傔偵丄CK AE1/AE3, CAM5.2, chromogranin A, synaptophysin, CD56側偳傪専摙偡傞昁梫偑偁傞偲婰嵹偝傟偰偄傑偡丅

彫嵶朎娻偺慻怐憸傪帵偟傑偡丅 彫宆偺棁妀偺庮釃嵶朎偐傜側傝丄峀斖側夡巰傪擣傔傑偡丅 庮釃嵶朎偺戝偒偝偼丄儕儞僷媴偺栺俁攞傑偱偱偡丅 彫嵶朎娻偲戝嵶朎恄宱撪暘斿娻偺幨恀偼摨偠攞棪偱嶣塭偟偰偄傑偡丅彫嵶朎娻偲戝嵶朎恄宱撪暘斿娻傪斾妑偟偰傒傑偡偲丄戝嵶朎恄宱撪暘斿娻偺曽偑嵶朎幙偑朙晉偱丄嵶朎偑戝偒偄偙偲偑傢偐傝傑偡丅

崿崌宆彫嵶朎娻
彫嵶朎娻偲旕彫嵶朎娻偑崿嵼偡傞庮釃偱丄捠忢丄態娻丄滸暯忋旂娻丄戝嵶朎娻丄戝嵶朎恄宱撪暘斿娻偑崿嵼偟傑偡偑丄傑傟偵朼悗嵶朎娻丄嫄嵶朎娻偑崿嵼偡傞偙偲傕偁傝傑偡丅

恄宱撪暘斿庮釃偺弍屻偺惗懚嬋慄

巹偨偪偼埲慜偵慻怐恌抐傪偟偨尨敪惈攛娻傪尒捈偟丄戝嵶朎恄宱撪暘斿娻偺昿搙偲偦偺梊屻傪専摙偟傑偟偨丅攛戝嵶朎娻傪恄宱撪暘斿暘壔偺桳柍偵傛傝戝嵶朎恄宱撪暘斿娻(large cell neuroendocrine carcinoma (LCNEC)), 恄宱撪暘斿暘壔傪帵偡戝嵶朎娻(large cell carcinoma with neuroendocrine differentiation (LCCND)), 恄宱撪暘斿庮釃偺宍懺傪帵偡戝嵶朎娻(large cell carcinoma with neuroendocrine morphology (LCCNM)), 捠忢偺戝嵶朎娻(classic large cell carcinoma (CLCC))偵暘椶偟傑偟偨丅LCNEC偲恌抐偟偨徢椺偺尦偺昦棟恌抐偼丄彫嵶朎娻拞娫嵶朎宆丄戝嵶朎娻丄掅暘壔偺態娻丄掅暘壔偺滸暯忋旂娻偱偟偨丅LCNEC, LCCND, LCCNM偺5擭惗懚棪偼偦傟偧傟27.4%丄22.2%丄18.2%偱丄CLCC偺5擭惗懚棪43.3%傛傝傕桳堄偵掅抣偱偟偨丅LCCNM偺椪彴僨乕僞偼LCNEC偲摨偠偱偟偨丅恄宱撪暘斿暘壔傪帵偡戝嵶朎娻偼梊屻偑埆偔丄慻怐妛揑偵恄宱撪暘斿暘壔傪妋擣偡傞偙偲偼丄椪彴揑偵傕堄媊偑偁傝傑偡丅
忋偺恾偼丄掕宆僇儖僠僲僀僪丄旕掕宆僇儖僠僲僀僪丄戝嵶朎恄宱撪暘斿娻丄彫嵶朎娻偺弍屻偺惗懚嬋慄偱偡丅僇儖僠僲僀僪偺梊屻偼椙岲偱丄旕掕宆僇儖僠僲僀僪偵偼嵞敪偟偨徢椺偑偁傝傑偟偨丅 戝嵶朎恄宱撪暘斿娻偼彫嵶朎娻偲摨條偵梊屻偑晄椙偱偟偨丅
壓偺恾偼丄戝嵶朎恄宱撪暘斿娻偵壔妛椕朄傪壛偊偨徢椺偲壛偊側偐偭偨徢椺偺弍屻偺惗懚嬋慄偱偡丅Retrospective側study偱偡偑丄戝嵶朎恄宱撪暘斿娻偵壔妛椕朄傪壛偊偨徢椺偼壛偊側偐偭偨徢椺偵斾傋偰梊屻偑椙岲偱偟偨丅

栤戣揰
戝嵶朎恄宱撪暘斿娻偲彫嵶朎娻偵娭偟偰丄昦棟堛娫偺恌抐堦抳棪偑掅偄偙偲偑曬崘偝傟偰偄傑偡丅 Travis傜偼丄摨偠昗杮傪俆恖偺攛愱栧偺昦棟堛偱恌抐偟傑偟偨丅彫嵶朎娻丄戝嵶朎恄宱撪暘斿娻偺慡椺偱俁恖埲忋偺恌抐偑堦抳偟傑偟偨丅偟偐偟丄慡堳偺恌抐偑堦抳偟偨偺偼丄彫嵶朎娻偺俈妱丄戝嵶朎恄宱撪暘斿娻偺係妱偱偟偨丅係恖偑堦抳偟偨偺偼彫嵶朎娻偺俋妱丄戝嵶朎恄宱撪暘斿娻偺俆妱偱偟偨丅

忋偺嵍抂偺恾偼丄懡偔偺昦棟堛偑戝嵶朎恄宱撪暘斿娻偲恌抐偟丄恀拞偺恾偼懡偔偺昦棟堛偑彫嵶朎娻偲恌抐偟傑偡丅塃抂偺恾偼丄彫嵶朎娻偲戝嵶朎恄宱撪暘斿娻偺椉曽偺摿挜傪桳偡傞偨傔丄昦棟堛偺恌抐偑堦抳偟傑偣傫丅

堷梡暥專

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