戞2斉

• 態朳態娻
• 擕摢態娻
• 嵶婥娗巟攛朎忋旂娻
• 擲塼嶻惗廩幚娻

戞3斉偍傛傃2004擭斉

• 態朳宆
• 擕摢宆
• 嵶婥娗巟攛朎忋旂娻
  • 擲塼旕嶻惗惈
  • 擲塼嶻惗惈
  • 擲塼嶻惗惈擲塼旕嶻惗惈崿崌宆偁傞偄偼晄妋掕宆
• 擲塼嶻惗廩幚宆
• 崿崌宆

態朳宆

娻嵶朎偼朎憙傪宍惉偟偰憹怋偟偰偄傑偡偑丄娗峯傪宍惉偟偰偄傑偡丅

擲塼嶻惗廩幚宆態娻

庮釃嵶朎偑廩幚惈偵憹怋偟偰偍傝丄戝嵶朎娻偲偺娪暿偑昁梫偱偡丅 塃偼alcian blue愼怓偱偡丅庮釃嵶朎偺嵶朎幙偵alcian blue梲惈偺擲塼傪懡悢擣傔傑偡丅 戝嵶朎娻偺拞偵丄彮悢偺庮釃嵶朎偵擲塼傪擣傔傞偙偲偑偁傝傑偡偑丄擲塼嶻惗廩幚宆偲偡傞偵偼丄2崅攞帇栰偱5屄埲忋偺庮釃嵶朎偵擲塼傪擖傟傞昁梫偑偁傝傑偡丅

崿崌宆態娻
態朳宆丄擕摢宆丄嵶婥娗巟攛朎忋旂娻丄擲塼嶻惗廩幚宆偑崿嵼偡傞庮釃偱偡丅

態娻偺摿庩宆偲偟偰

1. 戀帣宆態娻
2. 銹條態娻
3. 擲塼擷朎態娻
4. 報娐嵶朎娻
5. 扺柧嵶朎態娻

戀帣宆態娻

戀帣攛偵椶帡偟偨峔憿傪帵偡庮釃偼丄戞3斉偱偼崅暘壔戀帣宆態娻 偲側偭偰偄偄傑偡偑丄2004擭斉偱偼戀帣宆態娻 偲側偭偰偄傑偡丅 摿挜偼丄妀偺壓偁傞偄偼忋偵丄僌儕僐乕僎儞傪擖傟偨嬻朎傪擣傔丄暋嶨偵暘婒偟偨娗峯傪擣傔傑偡丅 懡妏宍嵶朎傛傝側傞岲巁惈偺morule傪擣傔傑偡丅 偙偺庮釃偼丄攛夎庮偵椶帡偟偰偄傑偡偑丄娫幙惈暘偵埆惈強尒偼尒傜傟傑偣傫丅 梊屻偼攛夎庮偵斾傋傞偲椙岲偱偡丅 30嵥戙傪僺乕僋偵丄傗傗彈惈桪埵偵敪惗偟傑偡[2,3]丅


銹條態娻
徚壔娗偺娻偵傒傜傟傞擲塼娻偵椶帡偟丄懡検偺擲塼偺拞偵庮釃嵶朎偑嶶嵼惈偵擣傔傜傟傞態娻偱偡丅

擲塼擷朎態娻
擲塼傪擖傟傞擷朎傪宍惉偟丄庮釃嵶朎偑攛朎暻偵増偭偰憹怋偟偰偄傞態娻偱偡丅

報娐嵶朎娻

堓娻偵傒傜傟傞報娐嵶朎娻偲摨條側丄嵶朎幙偵朙晉側擲塼傪擖傟傞庮釃嵶朎偐傜側傝傑偡丅 偙偺強尒偑傒傜傟偰傕丄偡偖偵堓娻偺揮堏偲峫偊傞偙偲偼偱偒傑偣傫丅 懠偺慻怐垷宆偺堦晹偵傒傜傟傞偙偲偑偁傝傑偡丅

扺柧嵶朎態娻丅

偙偺庮釃偼婥娗巟撪峯偵敪堢偟偨庮釃偱偡丅庮釃嵶朎偼扺柧偱丄PAS愼怓偱僌儕僐乕僎儞偑懚嵼偡傞偙偲偑傢偐傝傑偡丅 傢偢偐偵娗峯傪擣傔傞偨傔丄扺柧嵶朎態娻偲恌抐偟傑偟偨丅

揹巕尠旝嬀偱娤嶡偡傞偲丄妀廃埻偵懡検偺僌儕僐乕僎儞偺拁愊傪擣傔傑偟偨[4]丅

態娻偺栤戣揰
戝敿偺態娻偼崿崌宆偵暘椶偝傟丄2004擭斉偵偼栺俉侽亾偺態娻偑崿崌宆偱偁傞偲婰嵹偝傟偰偄傑偡丅
堎宆態庮條夁宍惉偲嵶婥娗巟攛朎忋旂娻傪娪暿偡傞媞娤揑婎弨偑偁傝傑偣傫丅
嵶婥娗巟攛朎忋旂娻偼攛朎暻偵増偭偰lepidic growth傪帵偡偲偝傟丄擕摢宆態娻偺偆偪丄屌桳偺婎幙傪桳偝側偄傕偺偼丄娪暿偡傞媞娤揑婎弨偑偁傝傑偣傫丅
嵶婥娗巟攛朎忋旂娻偼怹弫偺側偄庮釃偲掕媊偟偰偄傑偡偑丄娫幙怹弫傪媞娤揑偵敾抐偡傞婎弨偑偁傝傑偣傫丅

堷梡暥專

1. Hiroshima K, Iyoda A, Shibuya K, Hoshino H, Haga Y, Toyozaki T, Shiba M, Baba M, Fujisawa T, Ohwada H. Evidence of neoangiogenesis and an increase in the number of proliferating cells within the bronchial epithelium of smokers. Cancer 95, 1539-1545, 2002
2. Nakatani Y, Kitamura H, Inayama Y, Kamijo S, Nagashima Y, Shimoyama K, Nakamura N, Sano J, Ogawa N, Shibagaki T, Resl M, Mark EJ. Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms. Am. J. Surg. Pathol. 22, 399-411, 1998
3. Nakatani Y, Masudo K, Miyagi Y, Inayama Y, Kawano N, Tanaka Y, Kato K, Ito T, Kitamura H, Nagashima Y, Yamanaka S, Nakamura N, Sano J, Ogawa N, Ishiwa N, Notohara K, Resl M, Mark EJ. Aberrant nuclear localization and gene mutation of beta-catenin in low-grade adenocarcinoma of fetal lung type: up-regulation of the Wnt signaling pathway may be a common denominator for the development of tumors that form morules. Mod. Pathol. 15, 617-24, 2002
4. Iyoda A, Hiroshima K, Toyozaki T, Tsukamoto Y, Haga Y, Fujisawa T, Ohwada H. Clear cell adenocarcinoma with endobronchial polypoid growth. Pathol. Int. 50, 979-983, 2000
5. Hiroshima K, Shibuya K, Shimamura F, Toyozaki T, HagaY, Ohwada H, Iyoda A, Sekine Y, Iizasa T, Fujisawa T. Pulmonary large cell carcinoma with rhabdoid phenotype. Ultrastruct. Pathol. 27, 55-59, 2003
6. Hiroshima K, Abe S, Ebihara Y, Ogura S, Kikui M, Kodama T, Komatsu H, Saito Y, Sagawa M, Sato M, Tagawa Y, Nakamura S, Nakayama T, Baba M, Hanzawa S, Hirano T, Horai T. Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. Lung Cancer 48, 331-7, 2005
7. Iyoda A, Hiroshima K, Toyozaki T, Haga Y, Fujisawa T, Ohwada H. Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. Cancer 91, 1992-2000, 2001
8. Iyoda A, Hiroshima K, Baba M, Saitoh Y, Ohwada H, Fujisawa T. Pulmonary large cell carcinomas with neuroendocrine features are high-grade neuroendocrine tumors. Ann. Thorac. Surg. 73, 1049-1054, 2002
9. Iyoda A, Hiroshima K, Toyozaki T, Haga Y, Baba M, Fujisawa T, Ohwada H. Adjuvant chemotherapy for large cell carcinoma with neuroendocrine features. Cancer 92, 1108-1112, 2001
10. Travis WD, Gal AA, Colby TV, Klimstra DS, Falk R, Koss MN. Reproducibility of neuroendocrine lung tumor classification. Hum Pathol. 29, 272-279, 1998
11. Hiroshima K, Ishibashi M, Ohwada H, Kawano Y, Mizutani F, Hayashi Y. A case of adenocarcinoma of the lung with a spindle cell component. Acta Pathol. Jpn. 42, 841-846, 1992
12. Nakatani Y, Miyagi Y, Takemura T, Oka T, Yokoi T, Takagi M, Yokoyama S, Kashima K, Hara K, Yamada T, Nozawa A, Inayama Y, Sakamoto K, Ogawa N, Kitamura H, Resl M, Cho SH, Koss MN, Mark EJ. Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma. Am. J. Surg. Pathol. 28, 921-7, 2004

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