• TTF-1 (Thyroid transcription factor 1)
  • 攛態娻偲峛忬態娻偱梲惈丅懠偺態娻偱堿惈丅
• Surfactant apoprotein
  • 攛態娻偺堦晹偱梲惈丅
• Cytokeratin 7 / Cytokeratin 20
  • 攛態娻偼CK7(+), CK20(-)
  • 戝挵娻偼CK7(-), CK20(+), CDX-2(+)
• Estrogen receptor
  • 擕娻偱梲惈丅

徢椺侾

俀擭慜偵捈挵娻偵偰崅埵慜曽愗彍弍(mp, ly0, v0, Stage IA)偺婛墲偺偁傞攛庮釃傪帵偟傑偡丅 Follow up拞偵儗儞僩僎儞幨恀偱堎忢堿塭傪擣傔傑偟偨丅 Cytokeratin7偼婥娗巟忋旂丄婥娗巟態丄攛朎忋旂偵梲惈偱偡偑丄庮釃嵶朎偼堿惈偱偡丅Cytokeratin20偼攛慻怐偵偼堿惈偱偡偑丄庮釃嵶朎偼梲惈偱偡丅CDX-20傕摨條偵庮釃嵶朎偺傒梲惈偱偡丅TTF-1偼攛朎忋旂偵梲惈偱偡偑丄庮釃嵶朎偼堿惈偱偡丅 埲忋偺寢壥傛傝戝挵娻偺攛揮堏偲恌抐偟傑偟偨丅

徢椺俀

侾俈擭慜偵擕娻偺揈弌弍傪庴偗偨徢椺偱丄専恌偱嫻晹堎忢堿塭傪巜揈偝傟傑偟偨丅 塃忋偵擕娻偺慻怐憸丄攛偵攛娻偺慻怐憸傪帵偟傑偡丅 擕娻偺慻怐憸偵帡偰偄傑偡偑丄尨敪惈攛娻偲偟偰傕偍偐偟偔側偄強尒偱偡丅 柶塽愼怓偱TTF1(-), surfactant apoprotein偑堿惈偱丄estrogen receptor偑梲惈偱偁傞偙偲傛傝丄擕娻偺攛揮堏偱偁傞偙偲偑傢偐傝傑偡丅

徢椺俁

侾侾擭慜偵擕娻偺庤弍傪庴偗偰偄傑偡丅奝歶偱儗儞僩僎儞幨恀傪偲傝丄堎忢堿塭傪巜揈偝傟傑偟偨丅 揈弌偟偨攛庮釃偺慻怐憸偱偡丅 埲慜偺擕娻偺慻怐偼娗峯宍惉偑柧椖偱崱夞偺庮釃偲偼宍懺偑偙偲側傝傑偡偑丄揮堏惈庮釃偱偁傞偙偲傪斲掕偼偱偒傑偣傫丅 柶塽愼怓傪峴偄傑偟偨丅擕娻偱偼estrogen receptor偑梲惈偱丄崱夞偺攛庮釃偼estrogen receptor偑堿惈偱丄TTF-1偑梲惈偱偁傞偙偲傛傝攛尨敪偺態娻偲恌抐偟傑偟偨丅

堷梡暥專

1. Hiroshima K, Iyoda A, Shibuya K, Hoshino H, Haga Y, Toyozaki T, Shiba M, Baba M, Fujisawa T, Ohwada H. Evidence of neoangiogenesis and an increase in the number of proliferating cells within the bronchial epithelium of smokers. Cancer 95, 1539-1545, 2002
2. Nakatani Y, Kitamura H, Inayama Y, Kamijo S, Nagashima Y, Shimoyama K, Nakamura N, Sano J, Ogawa N, Shibagaki T, Resl M, Mark EJ. Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms. Am. J. Surg. Pathol. 22, 399-411, 1998
3. Nakatani Y, Masudo K, Miyagi Y, Inayama Y, Kawano N, Tanaka Y, Kato K, Ito T, Kitamura H, Nagashima Y, Yamanaka S, Nakamura N, Sano J, Ogawa N, Ishiwa N, Notohara K, Resl M, Mark EJ. Aberrant nuclear localization and gene mutation of beta-catenin in low-grade adenocarcinoma of fetal lung type: up-regulation of the Wnt signaling pathway may be a common denominator for the development of tumors that form morules. Mod. Pathol. 15, 617-24, 2002
4. Iyoda A, Hiroshima K, Toyozaki T, Tsukamoto Y, Haga Y, Fujisawa T, Ohwada H. Clear cell adenocarcinoma with endobronchial polypoid growth. Pathol. Int. 50, 979-983, 2000
5. Hiroshima K, Shibuya K, Shimamura F, Toyozaki T, HagaY, Ohwada H, Iyoda A, Sekine Y, Iizasa T, Fujisawa T. Pulmonary large cell carcinoma with rhabdoid phenotype. Ultrastruct. Pathol. 27, 55-59, 2003
6. Hiroshima K, Abe S, Ebihara Y, Ogura S, Kikui M, Kodama T, Komatsu H, Saito Y, Sagawa M, Sato M, Tagawa Y, Nakamura S, Nakayama T, Baba M, Hanzawa S, Hirano T, Horai T. Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. Lung Cancer 48, 331-7, 2005
7. Iyoda A, Hiroshima K, Toyozaki T, Haga Y, Fujisawa T, Ohwada H. Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. Cancer 91, 1992-2000, 2001
8. Iyoda A, Hiroshima K, Baba M, Saitoh Y, Ohwada H, Fujisawa T. Pulmonary large cell carcinomas with neuroendocrine features are high-grade neuroendocrine tumors. Ann. Thorac. Surg. 73, 1049-1054, 2002
9. Iyoda A, Hiroshima K, Toyozaki T, Haga Y, Baba M, Fujisawa T, Ohwada H. Adjuvant chemotherapy for large cell carcinoma with neuroendocrine features. Cancer 92, 1108-1112, 2001
10. Travis WD, Gal AA, Colby TV, Klimstra DS, Falk R, Koss MN. Reproducibility of neuroendocrine lung tumor classification. Hum Pathol. 29, 272-279, 1998
11. Hiroshima K, Ishibashi M, Ohwada H, Kawano Y, Mizutani F, Hayashi Y. A case of adenocarcinoma of the lung with a spindle cell component. Acta Pathol. Jpn. 42, 841-846, 1992
12. Nakatani Y, Miyagi Y, Takemura T, Oka T, Yokoi T, Takagi M, Yokoyama S, Kashima K, Hara K, Yamada T, Nozawa A, Inayama Y, Sakamoto K, Ogawa N, Kitamura H, Resl M, Cho SH, Koss MN, Mark EJ. Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma. Am. J. Surg. Pathol. 28, 921-7, 2004

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