Tokyo Women's Medical University

Graduate School of Medical Science

Field of Human Disease Models

About us

In medical and life science researches, to analyze the biological roles of genes, it is necessary to perform experiments using living animals. In 2017, Hiroaki Honda was assigned to this facility as a first full professor. Since 2018, this Institute has been working on student education and basic research with an associate professor, an assistant professor and other staffs.
In 2017, equipments necessary for developmental engineering, such as a macro-manipulator, an inverted microscope and microfuge were settled in a sophisticated room in the Institute, and in 2018, the first knock-out mouse was generated. After that, on requests from various Universities and Institutes, a number of genetically engineered mice, such as knock-out, knock-in and conditional knock-out mice, were created using the gene editing techniques.
We further analyze biological functions of target genes by generating genetically engineered mice. In addition, we elucidate pathophysiological mechanism of diseases by creating human disease models and develop novel molecular targeted therapies.

Research

1)Analysis of mechanisms of hematopoietic stem cell aging and development of hematopoietic malignancies using mutant mice for a histone modifying gene
2)Analysis of developmental mechanisms of urological malignancies using mutant mice for a histone modifying gene
3)Analysis of developmental abnormalities of central nervous system using mutant mice for a histone modifying gene
4)Analysis of developmental mechanisms of hematopoietic malignancies using mutant mice for a nuclear transcription factor
5)Analysis of developmental and progression mechanisms of hematopoietic malignancies using mutant mice for a ubiquitin ligase

Faculty

Professor: Hiroaki Honda
Associate Professor: Masayuki Iwasaki
Assistant Professor: Yasuyuki Sera

---