仭擣抦徢偵懳偡傞擼FDG-PET

丂擣抦徢姵幰偼尰嵼杮朚偵偍偄偰慡崙偱悇掕169枩恖傪挻偊2015擭偵偼250枩恖偵払偡傞偲尵傢傟偰偄傞乮2005擭岤惗楯摥徣悇寁乯丅65嵨埲忋偺崅楊幰偺13恖偵1恖丄85嵨埲忋偺挻崅楊幰偺幚偵4恖偵1恖偑擣抦徢偲峫偊傜傟傞丅崱屻桳岠側帯椕栻乮兝丄兞僙僋儗僞乕僛慾奞栻丄A兝儚僋僠儞側偳乯偑椪彴偵搊応偡傞忬嫷偵偁傞尰嵼丄擣抦徢偺憗婜恌抐丄憗婜夘擖偼嬞媫偺壽戣偱偁傞丅偙傟傑偱偵擣抦徢恌抐偵娭偟偰偼丄廬棃偐傜峴傢傟偰偄傞恄宱妛揑/恄宱怱棟妛揑昡壙丄MRI側偳偺宍懺夋憸傗SPECT/PET側偳偺婡擻夋憸丄悜塼拞偺傾儈儘僀僪抈敀傗冄僞儞僷僋偺専弌側偳偑桳梡偱偁傞偙偲偑傢偐偭偰偄傞丅偙偺拞偱旕怤廝揑側PET夋憸恌抐偵摿偵婜懸偑偐偐偭偰偄傞丅 擣抦徢姵幰偺偆偪丄栺50亅60%掱搙偑Alzheimer昦 (AD)偱偁傝丄傃傑傫惈Lewy彫懱昦 (DLB) 偲慜摢懁摢宆擣抦徢 (FTD) 偼偦傟偧傟15-25%偵偁偨傞丅AD姵幰偱偼揟宆揑偵偼屻晹懷忬夞偲摢捀懁摢梩旂幙丄偦偟偰恑峴婜偵偼慜摢梩偺摐戙幱偺掅壓傕傒傜傟傞丅偦傟偵斾妑偟偰FTD偱偼庡偵慜摢梩偲懁摢梩慜曽晹偺摐戙幱掅壓偑弶婜偐傜傒傜傟丄DLB偱偼摢捀屻摢旂幙傪娷傓屻曽椞堟偺掅壓偑傒傜傟傞偲偝傟傞1)丅撪懁懁摢梩丄摿偵奀攏椞堟偼AD孮偵偍偄偰摿偵崅搙偵摐戙幱掅壓偑傒傜傟傞丅 FDG-PET傪梡偄偨専嵏偵偰丄彨棃偺AD傊偺恑揥傪MCI乮寉搙擣抦忈奞丒Mild Cognitive Inpairment乯偺抜奒偱梊應偱偒傞偙偲偑婛偵帵偝傟偰偄傞丅尰嵼杮朚偱偼懡巤愝嫟摨慜岦偒僐儂乕僩尋媶偱偁傞SEAD-J乮Study on Diagnosis of Early AD-Japan乯側傜傃偵暷崙偺ADNI乮Alzheimer乫s Disease Neuroimaging Initiative乯傪儌僨儖偲偟偨J-ADNI偑憱偭偰偄傞丅廬偭偰丄悢擭偺偆偪偵妀堛妛専嵏偺桳梡惈偑丄偙傟傜偺慜岦偒椪彴尋媶偵傛傝妋擣偝傟傞偙偲偵側傠偆丅 偙偺傛偆側揰偱丄暷崙FDA偱偼2004擭傛傝丄Alzheimer昦偲慜摢宆擣抦徢偺娪暿偵偍偄偰FDG偺擣壜偑側偝傟偰偄傞丅尰嵼杮朚偱偼丄FDG-PET偺擼傊偺曐尟揔墳偵娭偟偰偼丄擼庮釃偲庤弍傪慜採偲偟偨偰傫偐傫偵尷傜傟偰偄傞丅廬偭偰AD側偳偺擣抦徢傗丄愐悜彫擼曄惈徢傗Parkinson昦側偳偺恄宱曄惈幘姵偵懳偡傞杮専嵏偼帺桼恌椕偺埖偄偲側偭偰偄傞丅杮朚偱傕憗婜偺曐尟揔墳偑朷傑傟傞丅 丂偟偐偟FDG-PET傕枩擻側傢偗偱偼側偔丄Mosconi傜2)偵傛傞偲丄FDG-PET偱偼DLB偺29亾丄FTD偺35亾偑AD椶帡偺夋憸曄壔傪掓偟偰偄偨偲偝傟丄AD偺DLB傗FTD偐傜偺娪暿擻偑丄sensitivity偼90%埲忋偲崅偄傕偺偺丄specificity 偼DLB 71%, FTD 65%偲掅偐偭偨偲曬崘偟偰偄傞丅崱屻偼擼婡擻掅壓傪斀塮偡傞摐戙幱傪傒傞FDG-PET偐傜堦曕偡偡傔偰丄AD偺尨場偲偝傟傞兝傾儈儘僀僪偺捑拝帺懱傪娤嶡偡傞Amyloid imaging偵傕婜懸偑偐偐偭偰偄傞3)丅

仭fig. 1

悢擭慜傛傝傕偺朰傟傪敪徢偟偨70嵨戙抝惈丅恄宱妛揑強尒偵堎忢側偟丅MMSE26揰丅崅師擼婡擻専嵏偱偼尵岅惈婰柫椡偺寉搙掅壓傪擣傔偨偑丄懠偺擣抦婡擻偼惓忢斖埻撪偱偁偭偨丅擼FDG-PET悈暯抐憸偱偼嵍桳堄偺慜摢梩丄懁摢梩偺摐戙幱偺掅壓傪擣傔傞丅

仭fig. 2

擭楊傪match偝偣偨20椺偺惓忢幰偺暯嬒夋憸偲斾妑偟丄摑寁妛揑偵桳堄偵掅壓偟偨晹埵傪擼昞夋憸偺搳塭偟偨3D-SSP夝愅夋憸丅嵍桪埵偺慜摢梩丄懁摢梩楢崌栰偵桳堄偵掅壓偟偨晹埵傪擣傔傞丅傑偨fig. 1偱偼柧妋偱偼側偐偭偨灦慜晹偺摐戙幱掅壓傕昤弌偝傟偰偄傞丅

• 1) Foster NL, Heidebrink JL, Clark CM, et al. FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer乫s disease. Brain. 130. 2616-2635. 2007.
• 2) Mosconi L, Tsui WH, Herholz K, et al. Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer乫s Disease, and Other Dementias. J Nucl Med. 49(3). 390-398. 2008.
• 3) Kllunk WE, Engler H, Nordberg A, et al. Imaging Brain Amyloid in Alzheimer乫s Disease with Pittsburgh Compound-B. Ann Neurol. 55:306-319. 2004.

仸偙偺専嵏偵偮偄偰偺偍栤偄崌傢偣偼丄03-3353-8111 撪慄 21010 妀堛妛丒PET専嵏幒傑偱丅

仾偙偺儁乕僕偺僩僢僾偵栠傞